Graciously compiled by Njardarson Group (The University of Arizona): Edon Vitaku, Elizabeth A. Ilardi, Jón T. Njarðarson are the top 200 drugs by total prescriptions written in the United States.
Top 200 Pharmaceutical Products by Total US Prescriptions
Notably, AstraZenica’s Nexium topped both charts, despite the fact that its remarkably similar to the now generically offered omeprozole (trade-name: Prilosec). Nexium is a single enantiomer (right-left hand version) of omeprozole, advertised for being less harsh on esophageal linings. However, research suggests otherwise:
All trials also found that 40mg and 20 mg of Esomeprozole showed no significant difference in EE Healing compared with Omeprozole 20mg.

Top 200 Drugs Last Year
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[...] week Airlats brought you a list of the top 200 drugs by US prescriptions, and wow was it popular. Once again, graciously compiled [...]